#2804 ALBUMINURIA IS ASSOCIATED WITH DECREASED SEVR AND ANKLE-BRACHIAL INDEX IN PATIENTS WITHOUT CKD

Abstract Background and Aims Albuminuria signifies subclinical vascular damage in the kidneys other organs is associated with systemic endothelial dysfunction increased future cardiovascular risk. Subendocardial viability ratio (SEVR) defined as diastolic to systolic pressure-time integral a marker of subendocardial perfusion. Reduced SEVR has been uncovered patients chronic kidney disease (CKD) simultaneous albuminuria. also considered risk factor for peripheral artery disease, especially additional atherosclerosis factors or diabetes mellitus. The aim our study was determine impact albuminuria on ankle-brachial index (ABI) without known CKD. Method We included 111 (73% male, mean age 64.2±9.3 years) that were hospitalized at Cardiology department between 2016-2020 due elective cardiac catheterization. determined by urine albumin creatinine (UACR) from random specimen. using applanation tonometry radial (Sphygmocor, Atcor Medical, Australia). Ankle-brachial measured an automated, non-invasive waveform analysis device (MESIÒ, Slovenia), ABI left right side used. Glomerular filtration rate estimated (eGFR) CKD-EPI 2009 equation. All data obtained prior catheterization only eGFR ³60 ml/min/1.73 m2 included. Statistical performed Package Social Sciences version 22.0 (SPSS Inc, USA). Results Basic descriptive statistics, comorbidities, medications are presented Tables 1 2. Spearmann's correlation test showed significant UACR (r = - 0.238; p 0.017) 0.304; 0.003). Multiple regression dependent variable waist-to-hip ratio, body mass (BMI), arterial hypertension, diabetes, dyslipidemia, independent variables, association (b 0.232; 0.029). same model used variable, found Conclusion independently decreased even absence